Clinical One Entry System is an AI-powered, contactless health platform that transforms building entrances into real-time screening, prevention, and response hubs. It reads core vital signs including temperature, heart rate, respiratory rate, and oxygen saturation through facial recognition, then analyzes them instantly to determine entry eligibility. Approved users receive far-UV hand sterilization and pass through an air shower to reduce pathogen carry-in. If infection risk is detected, the system restricts access, alerts staff, and activates isolation protocols. Beyond entry, Clinical One continues to monitor individuals inside the facility, detecting early signs of decline and triggering emergency response through automated nurse-call and telehealth integration. Designed for long-term care, nursing homes, and high-risk communities, it provides continuous, non-invasive protection across both entry and in-room environments. By preventing secondary infections and enabling real-time response, it strengthens digital health infrastructure for vulnerable populations while supporting staff with consistent, automated workflows.